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THERMAL SCIENCE
International Scientific Journal
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CHIKUNGUNYA VIRUS 2004-2025: MECHANISTIC BIOTHERMODYNAMIC MODEL OF CHIKUNGUNYA VIRUS ANTIGEN-RECEPTOR BINDING AND MULTIPLICATION DRIVEN BY GIBBS ENERGY
ABSTRACT
Chikungunya, Dengue and West Nile viruses are among the emerging arboviruses worldwide. In this research, chemical and thermodynamic properties of the Chikungunya virus were determined with the atom counting method and Patel-Erickson-Battley model, based on genetic sequences, protein sequences and virus morphology. This paper reports chemical and thermodynamic properties of the Chikungunya virus, which include molecular formulas, empirical formulas, molar masses, biosynthesis reactions, as well as thermodynamic properties of live matter, biosynthesis and antigen-receptor binding. Moreover, a mechanistic model was developed of pathogenesis during infection with Chikungunya virus. The mechanistic model is based on chemical and non-equilbrium thermodynamics. Based on the mechanistic model, an explanation is given why certain symptoms appear in Dengue infections, while other symptoms appear in Chikungunya infections, even though both are arboviruses. This methodology allows application of omics data to analyze virus-host interactions.
KEYWORDS
thermodynamics, enthalpy, entropy, Molecular formula, empirical formula, Thermochemical equations, Biosynthesis, Susceptibility, Permissiveness, Virus-host interaction
PAPER SUBMITTED: 2025-07-29
PAPER REVISED: 2025-11-01
PAPER ACCEPTED: 2025-11-10
PUBLISHED ONLINE: 2025-12-06
DOI REFERENCE: https://doi.org/10.2298/TSCI250729209P
CITATION EXPORT: view in browser or download as text file
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© 2026 Society of Thermal Engineers of Serbia. Published by the Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, Belgrade, Serbia. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International licence