TY - JOUR
TI - Chikungunya virus 2004-2025: Mechanistic biothermodynamic model of Chikungunya virus antigen-receptor binding and multiplication driven by Gibbs energy
AU - Popović Marko E
AU - Tadić Vojin M
AU - Pei Dong
JN - Thermal Science
PY - 2026
VL - 30
IS - 3
SP - 1905
EP - 1924
PT - Article
AB - Chikungunya, Dengue and West Nile viruses are among the emerging arboviruses worldwide. In this research, chemical and thermodynamic properties of the Chikungunya virus were determined with the atom counting method and Patel-Erickson-Battley model, based on genetic sequences, protein sequences and virus morphology. This paper reports chemical and thermodynamic properties of the Chikungunya virus, which include molecular formulas, empirical formulas, molar masses, biosynthesis reactions, as well as thermodynamic properties of live matter, biosynthesis and antigen-receptor binding. Moreover, a mechanistic model was developed of pathogenesis during infection with Chikungunya virus. The mechanistic model is based on chemical and non-equilbrium thermodynamics. Based on the mechanistic model, an explanation is given why certain symptoms appear in Dengue infections, while other symptoms appear in Chikungunya infections, even though both are arboviruses. This methodology allows application of omics data to analyze virus-host interactions.
DO - 10.2298/TSCI250729209P
ER -